Beyer D C
Radiation Oncologists of Central Arizona, Phoenix 85013.
Radiology. 1991 Feb;178(2):569-71. doi: 10.1148/radiology.178.2.1987626.
A retrospective evaluation was performed with records of 128 patients with 146 eyes that underwent applications of strontium-90 after pterygium excisions performed between 1982 and 1988. With a median follow-up of 13 months, 135 eyes were evaluable. Most pterygia (127 of 135) were treated with a single postoperative application of Sr-90 that delivered 3,000 cGy of beta radiation in one fraction. The actuarial freedom from relapse was 87%; all recurrences occurred within the first 18 months, and 46% of these within the first 3 months. Of the 13 recurrences, 10 have been re-treated with surgery and a second course of beta irradiation with excellent results. All eight eyes for which follow-up was available had no evidence of disease. The ultimate control rate was 96.3% for the series. Correlation of various treatment parameters, including age, bilaterality, prior recurrence, and interval from surgery to irradiation, was performed, and no statistically significant difference was seen. No serious complications have developed. Transient conjunctivitis and photophobia were almost universally seen, with five cases lasting beyond 5 months. The authors conclude that a single application of Sr-90 after surgery is effective and safe in managing pterygia.
对1982年至1988年间行翼状胬肉切除术后应用锶-90的128例患者的146只眼的记录进行了回顾性评估。中位随访时间为13个月，135只眼可进行评估。大多数翼状胬肉（135只中的127只）在术后单次应用锶-90，单次给予3000厘戈瑞的β射线辐射。无复发生存率为87%；所有复发均发生在最初18个月内，其中46%发生在最初3个月内。在13例复发中，10例已再次接受手术及第二疗程的β射线照射，效果良好。所有有随访记录的8只眼均无疾病迹象。该系列的最终控制率为96.3%。对包括年龄、双侧性、既往复发情况以及手术至照射间隔等各种治疗参数进行了相关性分析，未发现有统计学意义的差异。未出现严重并发症。几乎所有患者都出现了短暂性结膜炎和畏光症状，有5例持续时间超过5个月。作者得出结论，术后单次应用锶-90治疗翼状胬肉有效且安全。
