对未经手术切除的原发性和复发性翼状胬肉进行锶-90/钇-90β射线单纯照射的前瞻性研究。长期随访的临床结果。
Prospective study of exclusive strontium-/yttrium-90 beta-irradiation of primary and recurrent pterygia with no prior surgical excision. Clinical outcome of long-term follow-up.
作者信息
Vastardis Iraklis, Pajic Bojan, Greiner Richard H, Pajic-Eggspuehler Brigitte, Aebersold Daniel M
机构信息
Ophthalmology Clinic Pallas, Olten, Switzerland.
出版信息
Strahlenther Onkol. 2009 Dec;185(12):808-14. doi: 10.1007/s00066-009-2000-1.
PURPOSE
To evaluate the consecutive treatment results regarding pterygium recurrence and the efficacy of exclusive strontium-/yttrium-90 beta-irradiation for primary and recurrent pterygia and to analyze the functional outcome.
PATIENTS AND METHODS
Between October 1974 and December 2005, 58 primary and 21 recurrent pterygia were exclusively treated with strontium-/yttrium-90 beta-irradiation with doses ranging from 3,600 to 5,500 cGy. The follow-up time was 46.6 +/- 26.7 months, with a median of 46.5 months.
RESULTS
The treatment led to a size reduction in all pterygia (p < 0.0001). Neither recurrences nor side effects were observed during therapy and follow-up in this study. Best-corrected visual acuity increased (p = 0.0064). Corneal astigmatism was reduced in recurrent pterygia (p = 0.009).
CONCLUSION
Exclusive strontium-/yttrium-90 beta-irradiation of pterygia is a very efficient and well-tolerated treatment, with remarkable aesthetic and rehabilitative results in comparison to conventional treatments, especially for recurrent lesions which have undergone prior surgical excision.
目的
评估翼状胬肉复发的连续治疗结果以及锶 - /钇 - 90β射线单独照射治疗原发性和复发性翼状胬肉的疗效，并分析功能结局。
患者与方法
1974年10月至2005年12月期间，58例原发性翼状胬肉和21例复发性翼状胬肉接受了剂量范围为3600至5500厘戈瑞的锶 - /钇 - 90β射线单独照射。随访时间为46.6±26.7个月，中位数为46.5个月。
结果
治疗使所有翼状胬肉的大小减小（p < 0.0001）。在本研究的治疗和随访期间，未观察到复发或副作用。最佳矫正视力提高（p = 0.0064）。复发性翼状胬肉的角膜散光减少（p = 0.009）。
结论
翼状胬肉的锶 - /钇 - 90β射线单独照射是一种非常有效且耐受性良好的治疗方法，与传统治疗相比，具有显著的美学和康复效果，特别是对于先前已接受手术切除的复发性病变。
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