Kovtuniak N A, Bordiakovskaia L G
Probl Endokrinol (Mosk). 1977 Mar-Apr;23(2):99-103.
The authors investigated changes in the content of collagen, noncollagen proteins, total glycoproteins, glycosaminoglycuronans in the aortic tissue of hypophysectomized rats with due regard for the regulatory effects of STH, ACTH and TTH. Replacement STH therapy led to an increase of oxyproline, hexuronic acids, hexoses in the aortic tissue of the hypophysectomized rats. With the action of ACTH under conditions of hypophysectomy there was a marked increase in the content of glyco- and mucoproteins and a reduction of glycosamines in the aortic tissue. The amount of glycosaminoglycuronans, collagen increased considerably under the effect of TTH in the aortic tissue of the hypophysectomized rats; as to the glyco- and mucoprotein content--in remained unchanged. ACTH, TTH and STH were administered from the 15th to the 21st day after hypophysectomy.
作者研究了垂体切除大鼠主动脉组织中胶原蛋白、非胶原蛋白、总糖蛋白、糖胺聚糖含量的变化，并充分考虑了生长激素（STH）、促肾上腺皮质激素（ACTH）和促甲状腺激素（TTH）的调节作用。补充生长激素治疗导致垂体切除大鼠主动脉组织中羟脯氨酸、己糖醛酸、己糖含量增加。在垂体切除条件下，促肾上腺皮质激素作用后，主动脉组织中糖蛋白和粘蛋白含量显著增加，糖胺含量降低。垂体切除大鼠主动脉组织在促甲状腺激素作用下，糖胺聚糖和胶原蛋白含量显著增加；而糖蛋白和粘蛋白含量则保持不变。促肾上腺皮质激素、促甲状腺激素和生长激素在垂体切除术后第15天至第21天给药。
