Kovtuniak N A, Bordiakovskaia L G
Probl Endokrinol (Mosk). 1975 May-Jun;21(3):92-5.
An experimental study was make of the changes in respiration and of the oxidative phosphorylation in the hepatic mitochondria of the hypophysectomized albino rats, with consideration to the regulatory effects of the ACTH, TTH, and STH. There was an intensification of the conjugation of the oxidative and of the phosphorylation processes in the mitochondria of the liver of hypophysectomized albino rats as a result of ACTH replacement therapy in a dose of 3 Units per 100 g of weight. TTH given in a dose of 0.03 IU per 100 g of weight under conditions of hypophysectomy stimulated oxidation of alpha-ketoglutaric acid in the mitochondria of the liver of albino rats; phosphorylation remained reduced, i.e. there was seen a dissociation of the process of oxidative phosphorylation. As a result of replacement therapy with the STH given in a dose of 10 gamma per 100 g of weight the energy metabolism in the liver of hypophysectomized albino rats changed in the direction of an increase in the P/O coefficient of the hepatic mitochondria. ACTH, TTH, and STH were given from the 15th to the 21st days after hypophysectomy, twice a day, subcutaneously.
对白鼠垂体切除术后肝脏线粒体的呼吸变化及氧化磷酸化进行了实验研究，同时考虑了促肾上腺皮质激素（ACTH）、促甲状腺激素（TTH）和生长激素（STH）的调节作用。每100克体重给予3单位剂量的ACTH替代疗法，可使垂体切除术后白化病大鼠肝脏线粒体中的氧化与磷酸化过程的偶联增强。在垂体切除的条件下，每100克体重给予0.03国际单位剂量的TTH，可刺激白化病大鼠肝脏线粒体中α-酮戊二酸的氧化；磷酸化作用仍然减弱，即氧化磷酸化过程出现了解偶联。每100克体重给予10微克剂量的STH替代疗法，使垂体切除术后白化病大鼠肝脏的能量代谢朝着肝脏线粒体P/O系数增加的方向变化。垂体切除术后第15天至第21天，每天皮下注射两次ACTH、TTH和STH。
