高场 MRI 在帕金森病研究中的潜在作用。

Potential role of high-field MRI for studies in Parkinson's disease.

机构信息

Centre for Imaging of Neurodegenerative Diseases, Veterans Affairs Medical Center, San Francisco, California 94121, USA.

出版信息

Mov Disord. 2009;24 Suppl 2:S684-90. doi: 10.1002/mds.22647.

DOI:10.1002/mds.22647

PMID:19877239

Abstract

Recent advancements in high field magnetic resonance imaging (MRI) technology (3 T and higher), providing increased signal sensitivity and images with more prominent contrasts intrinsic to the brain, offer new opportunities for assessing brain alterations in Parkinson's disease (PD). In this article, the principle benefits of high field MRI for PD research are described and new findings at high magnetic fields are reviewed. Several high field MRI methodologies, including structural MRI, imaging of brain iron, diffusion tensor imaging, arterial spin labeling perfusion imaging, rotating frame imaging, and magnetic resonance spectroscopy, are critically reviewed for their potential roles in studies of PD.

摘要

近年来，高场磁共振成像（MRI）技术（3T 及以上）取得了进展，提高了信号灵敏度，使大脑固有对比度更明显，为评估帕金森病（PD）患者的大脑改变提供了新的机会。本文描述了高场 MRI 在 PD 研究中的主要优势，并综述了高磁场下的新发现。对几种高场 MRI 方法学，包括结构 MRI、脑铁成像、弥散张量成像、动脉自旋标记灌注成像、旋转框架成像和磁共振波谱，从其在 PD 研究中的潜在作用进行了批判性回顾。