包裹在脂质囊泡中的脊髓灰质炎病毒的生物学特性：抗病毒细胞中的抗体抗性和感染性。
Biological properties of poliovirus encapsulated in lipid vesicles: antibody resistance and infectivity in virus-resistant cells.
作者信息
Wilson T, Papahadjopoulos D, Taber R
出版信息
Proc Natl Acad Sci U S A. 1977 Aug;74(8):3471-5. doi: 10.1073/pnas.74.8.3471.
Abstract
We present evidence that poliovirus can be encapsulated in synthetic large phospholipid vesicles. The virus associated with the vesicles is found to be (i) resistant to antiserum against poliovirus and (ii) infectious for cells that are normally resistant to virus infection because of a membrane restriction. Our interpretation of these results is that the virus is entrapped in the interior aqueous space of the vesicles and that this vesicle-associated virus is introduced directly into the cytoplasm of the cells via fusion of the vesicles with the cellular plasma membrane, bypassing the surface receptor-mediated restriction.
摘要
我们提供的证据表明，脊髓灰质炎病毒可被包裹于合成的大磷脂囊泡中。与囊泡相关的病毒被发现具有以下特性：（i）对脊髓灰质炎病毒抗血清具有抗性；（ii）对于因膜限制而通常对病毒感染具有抗性的细胞具有感染性。我们对这些结果的解释是，病毒被困在囊泡内部的水相中，并且这种与囊泡相关的病毒通过囊泡与细胞质膜的融合直接被引入细胞的细胞质中，从而绕过了表面受体介导的限制。
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