Department of Neonatology, Bnai Zion Medical Center, Technion, Israel Institute of Technology, 47 Golomb Street, POB 4940, Haifa 31048, Israel.
J Pediatr. 2010 Feb;156(2):209-14. doi: 10.1016/j.jpeds.2009.09.006. Epub 2009 Oct 31.
To assess the safety and prebiotic effects of lactulose in preterm infants.
This was a prospective, double-blinded, placebo-controlled, single-center study in 23- to 34-weeks premature infants. The study group received 1% lactulose, and control infants received 1% dextrose in all feeds (human milk or formula).
Twenty-eight infants participated (15 lactulose, 13 placebo). Small doses of lactulose appeared to be safe and did not cause diarrhea. Premature infants on lactulose had more Lactobacilli-positive stool cultures that appeared earlier with larger number of colonies. The lactulose group tended to have less intolerance to enteral feedings, to reach full oral feeds earlier, and to be discharged home earlier. They also tended to have fewer episodes of late-onset sepsis, lower Bell stage necrotizing enterocolitis, and their nutritional laboratory indices were better, especially calcium and total protein.
This pilot study supports the safety of supplementing preterm infants' feeds with low doses of lactulose. It also demonstrated trends that may suggest positive prebiotic effects.
评估乳果糖在早产儿中的安全性和益生元作用。
这是一项前瞻性、双盲、安慰剂对照、单中心研究，纳入 23-34 周早产儿。研究组接受 1%乳果糖，对照组接受所有喂养（人乳或配方奶）中添加 1%葡萄糖。
28 名婴儿参与（15 名乳果糖，13 名安慰剂）。小剂量乳果糖似乎是安全的，不会引起腹泻。服用乳果糖的早产儿粪便中乳杆菌阳性培养更早出现，且菌落数量更多。乳果糖组对肠内喂养的不耐受性更小，更早达到全口服喂养，更早出院。他们也更少出现晚发型败血症发作，Bell 分期坏死性小肠结肠炎发生率更低，其营养实验室指标更好，尤其是钙和总蛋白。
这项初步研究支持在早产儿喂养中添加低剂量乳果糖的安全性。它还表明可能具有积极的益生元作用的趋势。
