Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Yuseong-gu, Kuseong-dong, 373-1 Daejeon, 305-701 South Korea.
Brain Res. 2010 Mar 4;1317:211-7. doi: 10.1016/j.brainres.2009.10.057. Epub 2009 Oct 30.
The magnetic field has been regarded as both harmful and beneficial for its applications on human brains including transcranial magnetic stimulation (TMS), but its effects still remain in question. Here, we determined using single photon emission computed tomography (SPECT) if 0.3-T static magnetic field could alter regional cerebral blood flow (rCBF) in target and other brain regions in healthy subjects. The permanent static magnet (0.3 T, unipolar, disk shaped, 4 cm diameter and 1 cm thick) was placed on the right frontotemporal region of the brain for each of 14 healthy subjects. Tc-99m ECD perfusion SPECT was taken to compare the CBF patterns in the subjects exposed to the static magnet field with those of the resting and sham conditions. We found that the rCBF was significantly increased in the right frontal and parietal regions and the right insula. On the other hand, rCBF was rather decreased in the left frontal and left parietal regions (P<0.05). These results of this basic study suggest that 0.3-T static magnetic field induces an increase in rCBF in the targeted brain areas non-invasively, which may result from a decrease in rCBF in contralateral regions.
磁场因其在包括经颅磁刺激（TMS）在内的人类大脑应用中的双重作用而备受关注，但其影响仍存在争议。在这里，我们使用单光子发射计算机断层扫描（SPECT）来确定 0.3-T 静磁场是否会改变健康受试者的目标和其他大脑区域的局部脑血流（rCBF）。将永久静磁体（0.3 T，单极，盘状，直径 4 厘米，厚 1 厘米）放置在 14 名健康受试者的右额颞区。对 Tc-99m ECD 灌注 SPECT 进行了拍摄，以比较暴露于静磁场的受试者的 CBF 模式与静息和假状态下的 CBF 模式。我们发现，右额区和顶区以及右岛叶的 rCBF 明显增加。另一方面，左额叶和左顶叶的 rCBF 则减少（P<0.05）。这项基础研究的结果表明，0.3-T 静磁场可无创性地增加目标大脑区域的 rCBF，这可能是由于对侧区域 rCBF 的减少所致。
