Department of Mechanical Engineering and Science, Graduate School of Engineering, Kyoto University, Kyoto 606-8502, Japan ; Research Section for Magnetics, Product Development Department, Development Division, PIP Company, Osaka 540-0011, Japan.
Research Section for Magnetics, Product Development Department, Development Division, PIP Company, Osaka 540-0011, Japan ; Research Center for Frontier Medical Engineering, Chiba University, Chiba 263-8522, Japan.
Evid Based Complement Alternat Med. 2013;2013:746968. doi: 10.1155/2013/746968. Epub 2013 Dec 17.
We investigated the SMF effects on hemodynamics in the caudal artery-ligated rat as an in vivo ischemia model using noninvasive near-infrared spectroscopy (NIRS) combined with power spectral analysis by fast Fourier transform. Male Wistar rats in the growth stage (10 weeks old) were randomly assigned into four groups: (i) intact and nonoperated cage control (n = 20); (ii) ligated alone (n = 20); (iii) ligated and implanted with a nonmagnetized rod (sham magnet; n = 22); and (vi) ligated and implanted with a magnetized rod (n = 22). After caudal artery ligation, a magnetized or unmagnetized rod (maximum magnetic flux density of 160 mT) was implanted transcortically into the middle diaphysis of the fifth caudal vertebra. During the experimental period of 7 weeks, NIRS measurements were performed in 3- , 5- , and 7-week sessions and the vasomotion amplitude and frequency were analyzed by fast Fourier transform. Exposure for 3-7 weeks to the SMF significantly contracted the increased vasomotion amplitude in the ischemic area. These results suggest that SMF may have a regulatory effect on rhythmic vasomotion in the ischemic area by smoothing the vasomotion amplitude in the early stage of the wound healing process.
我们使用非侵入性近红外光谱 (NIRS) 结合快速傅里叶变换的功率谱分析，研究了 SMF 对结扎尾动脉大鼠（作为体内缺血模型）的血液动力学的影响。处于生长阶段的雄性 Wistar 大鼠（10 周龄）被随机分为四组：（i）完整且未手术的笼对照（n = 20）；（ii）仅结扎（n = 20）；（iii）结扎并植入非磁化棒（假磁体；n = 22）；和（vi）结扎并植入磁化棒（n = 22）。在结扎尾动脉后，将磁化或非磁化棒（最大磁通密度为 160mT）经皮质植入第五尾椎的中间骨干。在 7 周的实验期间，进行了 3-、5-和 7 周的 NIRS 测量，并通过快速傅里叶变换分析血管运动幅度和频率。暴露于 SMF 3-7 周可显著收缩缺血区增加的血管运动幅度。这些结果表明，SMF 可能通过平滑愈合过程早期的血管运动幅度，对缺血区的节律性血管运动具有调节作用。
