Duffy Anne, Alda Martin, Hajek Tomas, Grof Paul
MD, Department of Psychiatry, Dalhousie University IWK Health Centre, 5850/5980 University Avenue, P.O. Box 9700, Halifax, Nova Scotia, Canada B3K 6R8.
Br J Psychiatry. 2009 Nov;195(5):457-8. doi: 10.1192/bjp.bp.108.062810.
We studied the course of major mood disorders in the offspring of parents with well-characterised bipolar disorder prospectively for up to 15 years. All consenting offspring were assessed annually or anytime symptomatic. The participants began to develop major mood episodes in adolescence and not before. The index major mood episode was almost always depressive, as were the first few recurrences. Onsets and recurrences continued throughout the observation period into adulthood. We did not find evidence of pre-pubertal mania. In summary, adolescence marks the beginning of the high-risk period for major mood episodes related to bipolar disorder.
我们对患有特征明确的双相情感障碍的父母的后代的主要心境障碍病程进行了长达15年的前瞻性研究。所有同意参与的后代每年或出现症状时随时接受评估。参与者在青春期开始出现主要心境发作，而非在此之前。索引性主要心境发作几乎总是抑郁性的，最初几次复发也是如此。发作和复发在整个观察期持续到成年期。我们未发现青春期前躁狂的证据。总之，青春期标志着与双相情感障碍相关的主要心境发作高危期的开始。
