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欧洲心力衰竭患者心脏再同步治疗(心脏再同步治疗和植入式心脏复律除颤器)的实施:2004 年至 2008 年的变化。

Implementation of device therapy (cardiac resynchronization therapy and implantable cardioverter defibrillator) for patients with heart failure in Europe: changes from 2004 to 2008.

机构信息

Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

出版信息

Eur J Heart Fail. 2009 Dec;11(12):1143-51. doi: 10.1093/eurjhf/hfp149. Epub 2009 Nov 1.

Abstract

AIMS

Heart failure (HF) patients increasingly receive device therapy, either an implantable cardioverter defibrillator (ICD) or a biventricular pacemaker, also called cardiac resynchronization therapy (CRT), or a CRT device with an ICD (CRT-D). However, epidemiological data on the use of device therapy in Europe are limited.

METHODS AND RESULTS

Data on implantation rates for conventional pacemakers, ICD, CRT, and CRT-D in 15 Western European countries were obtained from the Eucomed Registry for the 5-year period 2004-2008. Implantation of conventional pacemakers increased by 9% in Europe over the 5 years (reaching 907/million in 2008) and there were significant differences between countries. Implantable cardioverter defibrillator implantations increased by 75% from 80/million in 2004 to 140/million in 2008, and differences between countries were larger than those for conventional pacemakers. Implantation rates for CRT-P alone increased slightly from 2004 to 2006, but remained at 25/million thereafter in Europe overall. The total number of CRT implants (CRT-P and -D) markedly increased from 46/million in 2004 to 99/million in 2008 (115%), but this was mainly due to more CRT-D implants, i.e. an increase in the proportion of CRT-D (from 55% in 2004 to 75% in 2008). Implantation rates for ICD, CRT, and CRT-D remained markedly different throughout the study period between countries.

CONCLUSION

Implantation rates of devices for HF, in particular ICD and CRT-D, have increased significantly between 2004 and 2008 in Europe, but there remain major differences between countries.

摘要

目的

心力衰竭(HF)患者越来越多地接受设备治疗,包括植入式心脏复律除颤器(ICD)或双心室起搏器,也称为心脏再同步治疗(CRT),或带有 ICD 的 CRT 设备(CRT-D)。然而,欧洲关于设备治疗使用的流行病学数据有限。

方法和结果

从欧洲药物管理局注册处获得了 2004-2008 年 5 年间 15 个西欧国家常规起搏器、ICD、CRT 和 CRT-D 的植入率数据。5 年内,欧洲常规起搏器的植入量增加了 9%(2008 年达到 907/百万),各国之间存在显著差异。ICD 的植入量从 2004 年的 80/百万增加到 2008 年的 140/百万,增加了 75%,各国之间的差异大于常规起搏器。单独的 CRT-P 植入率从 2004 年到 2006 年略有增加,但此后在整个欧洲一直保持在 25/百万。CRT 植入总数(CRT-P 和 -D)从 2004 年的 46/百万显著增加到 2008 年的 99/百万(增加了 115%),但这主要是由于更多的 CRT-D 植入,即 CRT-D 的比例增加(从 2004 年的 55%增加到 2008 年的 75%)。整个研究期间,各国之间 ICD、CRT 和 CRT-D 的植入率仍然存在显著差异。

结论

2004 年至 2008 年间,欧洲 HF 设备的植入率,特别是 ICD 和 CRT-D,显著增加,但各国之间仍存在重大差异。

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