一种具有双重 DNA 结合和组蛋白去乙酰化酶抑制活性的新型抗癌双功能铂类药物候选物。
A novel anti-cancer bifunctional platinum drug candidate with dual DNA binding and histone deacetylase inhibitory activity.
机构信息
Centre for Synthesis and Chemical Biology, Department of Pharmaceutical & Medicinal Chemistry, Royal College of Surgeons in Ireland (RCSI), Dublin 2, Ireland.
出版信息
Chem Commun (Camb). 2009 Nov 28(44):6735-7. doi: 10.1039/b916715c. Epub 2009 Oct 12.
DOI:10.1039/b916715c
PMID:19885462
Abstract
The successful design and synthesis of a novel multifunctional platinum drug candidate with DNA binding, histone deacetylase inhibitory activity and enhanced selectivity for cancer cells are described.
摘要
描述了一种新型多功能铂类药物候选物的成功设计和合成，该候选物具有 DNA 结合、组蛋白去乙酰化酶抑制活性，并增强了对癌细胞的选择性。
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