含双（硫代烷基）二碳-闭式-十二硼烷（12）配体的双核铂（II）配合物的合成与抗癌活性
Synthesis and anti-cancer activity of dinuclear platinum(II) complexes containing bis(thioalkyl)dicarba-closo-dodecaborane(12) ligands.
作者信息
Woodhouse Susan L, Ziolkowski Erin J, Rendina Louis M
机构信息
School of Chemistry and Physics, The University of Adelaide, Adelaide, South Australia 5005, Australia.
出版信息
Dalton Trans. 2005 Sep 7(17):2827-9. doi: 10.1039/b508340k. Epub 2005 Jul 25.
DOI:10.1039/b508340k
PMID:16094469
Abstract
A series of novel, dinuclear (2,2':6',2''-terpyridine)platinum(ii) complexes containing bis(thioalkyl)-dicarba-closo-dodecaborane(12)(carborane) ligands were prepared and characterised, and their preliminary anti-cancer characteristics have been determined in vitro; the complexes are the first examples of bis-intercalator complexes containing a boron-rich carborane cage.
摘要
制备并表征了一系列含有双（硫代烷基）-二碳-闭式-十二硼烷（12）（碳硼烷）配体的新型双核（2,2':6',2''-三联吡啶）铂（II）配合物，并在体外测定了它们初步的抗癌特性；这些配合物是含有富硼碳硼烷笼的双嵌入剂配合物的首例。
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