肝细胞生长因子介导的间充质干细胞对凋亡神经元和心肌细胞的趋化作用。
Hepatocyte growth factor-mediated attraction of mesenchymal stem cells for apoptotic neuronal and cardiomyocytic cells.
机构信息
Institute for Transplantation Diagnostics and Cell Therapeutics, Heinrich Heine University Medical Center, Moorenstrasse 5, Bldg. 14.80, 40225, Düsseldorf, Germany.
出版信息
Cell Mol Life Sci. 2010 Jan;67(2):295-303. doi: 10.1007/s00018-009-0183-3. Epub 2009 Nov 3.
Abstract
Human bone marrow-derived mesenchymal stem cells (MSC) home to injured tissues and have regenerative capacity. In this study, we have investigated in vitro the influence of apoptotic and necrotic cell death, thus distinct types of tissue damage, on MSC migration. Concordant with an increased overall motility, MSC migrated towards apoptotic, but not vital or necrotic neuronal and cardiac cells. Hepatocyte growth factor (HGF) was expressed by the apoptotic cells only. MSC, in contrast, revealed expression of the HGF-receptor, c-Met. Blocking HGF bioactivity resulted in significant reduction of MSC migration. Moreover, recombinant HGF attracted MSC in a dose-dependent manner. Thus, apoptosis initiates chemoattraction of MSC via the HGF/c-Met axis, thereby linking tissue damage to the recruitment of cells with regenerative potential.
摘要
人骨髓间充质干细胞（MSC）归巢到损伤组织，并具有再生能力。在这项研究中，我们研究了凋亡和坏死细胞死亡（即不同类型的组织损伤）对 MSC 迁移的体外影响。MSC 向凋亡细胞而不是存活或坏死的神经元和心肌细胞迁移，与整体迁移能力增强一致。只有凋亡细胞表达肝细胞生长因子（HGF）。相比之下，MSC 表现出 HGF 受体 c-Met 的表达。阻断 HGF 的生物活性会导致 MSC 迁移显著减少。此外，重组 HGF 以剂量依赖性方式吸引 MSC。因此，凋亡通过 HGF/c-Met 轴启动 MSC 的趋化吸引，从而将组织损伤与具有再生潜能的细胞募集联系起来。
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本文引用的文献
1
Mesenchymal stem cells in health and disease.
Nat Rev Immunol. 2008 Sep;8(9):726-36. doi: 10.1038/nri2395.
2
Comparative proteomic analysis of mesenchymal stem cells derived from human bone marrow, umbilical cord, and placenta: implication in the migration.
Proteomics. 2009 Jan;9(1):20-30. doi: 10.1002/pmic.200701195.
3
Over-expression of hepatocyte growth factor in smooth muscle cells regulates endothelial progenitor cells differentiation, migration and proliferation.
Int J Cardiol. 2010 Jan 7;138(1):70-80. doi: 10.1016/j.ijcard.2008.10.042. Epub 2008 Dec 17.
4
Bone marrow-derived mesenchymal stem cells for the treatment of ischemic stroke.
J Clin Neurosci. 2009 Jan;16(1):12-20. doi: 10.1016/j.jocn.2008.05.006. Epub 2008 Nov 18.
5
Treatment of refractory acute GVHD with third-party MSC expanded in platelet lysate-containing medium.
Bone Marrow Transplant. 2009 Feb;43(3):245-51. doi: 10.1038/bmt.2008.316. Epub 2008 Sep 29.
6
High mobility group box 1 protein inhibits the proliferation of human mesenchymal stem cells and promotes their migration and differentiation along osteoblastic pathway.
Stem Cells Dev. 2008 Aug;17(4):805-13. doi: 10.1089/scd.2007.0276.
7
Mesenchymal stem cells and cardiac repair.
J Cell Mol Med. 2008 Oct;12(5B):1795-810. doi: 10.1111/j.1582-4934.2008.00457.x. Epub 2008 Aug 5.
8
Hepatocyte growth factor/c-MET axis-mediated tropism of cord blood-derived unrestricted somatic stem cells for neuronal injury.
J Biol Chem. 2008 Nov 21;283(47):32244-53. doi: 10.1074/jbc.M800862200. Epub 2008 Jul 15.
9
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Stem Cells. 2008 Aug;26(8):2173-82. doi: 10.1634/stemcells.2007-1104. Epub 2008 May 29.
10
Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study.
Lancet. 2008 May 10;371(9624):1579-86. doi: 10.1016/S0140-6736(08)60690-X.
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