University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA.
J Occup Environ Hyg. 2009 Dec;6(12):762-5. doi: 10.1080/15459620903158698.
The current mainstay of management of chronic beryllium disease involves cessation of beryllium exposure and use of systemic corticosteroids. However, there are no randomized controlled trials to assess the effect of these interventions on the natural history of this disease. Despite this limitation, it is prudent to remove patients with chronic beryllium disease from further exposure and consider treating progressive disease early with long-term corticosteroids. The effect of treatment should be monitored using pulmonary function tests and high-resolution computed tomography of the chest. However, once pulmonary fibrosis has developed, corticosteroid therapy cannot reverse the damage.
目前,慢性铍病的主要治疗方法包括停止铍暴露和使用全身性皮质类固醇。然而,目前尚无评估这些干预措施对该病自然史影响的随机对照试验。尽管存在这一局限性,但谨慎的做法是让患有慢性铍病的患者避免进一步接触铍,并考虑早期使用长期皮质类固醇治疗进行性疾病。应使用肺功能测试和胸部高分辨率计算机断层扫描来监测治疗效果。然而,一旦发生肺纤维化,皮质类固醇治疗就无法逆转损伤。