Bogucka Małgorzata, Giebułtowicz Joanna, Zawada Katarzyna, Wroczyński Piotr, Wierzchowski Jacek, Pietrzak Monika, Piekarczyk Piotr, Romanowska Katarzyna
Department of Drugs Analysis, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha St., PL-02097 Warsaw, Poland.
Acta Pol Pharm. 2009 Sep-Oct;66(5):477-82.
Oxidation status of the salivary aldehyde dehydrogenase (ALDH) was measured in healthy human population using two-assay fluorimetric method and compared with antioxidant capacity (ORAC) in non-smoking and heavy smokers group. Influence of high or low antioxidant diet was also examined. Except for the group of smokers, the salivary ALDH oxidation degree in human saliva was not correlated with antioxidant capacity. Simultaneously direct administration of the antioxidant-containing drug, Fluimucil, resulted in short-term, but statistically significant increase of the reduced (active) form of the enzyme, presumably due to a radical-scavenging activity of the drug.
采用双测定荧光法在健康人群中测量唾液醛脱氢酶（ALDH）的氧化状态，并与非吸烟组和重度吸烟组的抗氧化能力（ORAC）进行比较。还研究了高抗氧化剂饮食或低抗氧化剂饮食的影响。除吸烟组外，人唾液中唾液ALDH的氧化程度与抗氧化能力无关。同时，直接施用含抗氧化剂的药物福路米可（Fluimucil），导致该酶的还原（活性）形式出现短期但具有统计学意义的增加，这可能是由于该药物的自由基清除活性所致。
