Shennib H, Nguyen D
McGill University Lung Transplant Program, Montreal General Hospital, Quebec, Canada.
Ann Thorac Surg. 1991 Feb;51(2):335-40. doi: 10.1016/0003-4975(91)90824-a.
One of the dilemmas in the management of lung allotransplant recipients is our inability to precisely determine the cause of graft dysfunction. Differentiating between lung allograft infection, rejection, atelectasis, or ischemic injury remains a difficult task. Tests directed at identifying systemic abnormalities such as peripheral blood analysis so far have been nonspecific and unlikely to accurately and promptly represent changes occurring within the lungs. Transbronchial biopsy and bronchoalveolar lavage have emerged as two methods with the most potential for aiding in the establishment of diagnosis. This review attempts to provide the readers with a current knowledge of the cellular events in lung allograft and the status of bronchoalveolar lavage in experimental and clinical lung transplantation.
肺同种异体移植受者管理中的难题之一是我们无法精确确定移植物功能障碍的原因。区分肺同种异体移植感染、排斥反应、肺不张或缺血性损伤仍然是一项艰巨的任务。迄今为止，旨在识别全身异常的检查，如外周血分析，一直缺乏特异性，不太可能准确及时地反映肺部发生的变化。经支气管活检和支气管肺泡灌洗已成为最有潜力帮助确诊的两种方法。本综述旨在为读者提供有关肺同种异体移植中细胞事件以及支气管肺泡灌洗在实验性和临床肺移植中的现状的最新知识。
