弹性蛋白酶抑制因子是蛋白酶3的有效抑制剂。
Elafin is a potent inhibitor of proteinase 3.
作者信息
Wiedow O, Lüademann J, Utecht B
机构信息
Department of Dermatology, University of Kiel, FRG.
出版信息
Biochem Biophys Res Commun. 1991 Jan 15;174(1):6-10. doi: 10.1016/0006-291x(91)90476-n.
Elafin, a human skin derived inhibitor of human leukocyte elastase, was tested for inhibitory activity against proteinase 3, an elastin degrading proteinase of neutrophils. The inhibitory activity of elafin was compared with antileukoprotease and eglin C. Elafin proved to be a potent inhibitor of elastin-FITC degradation showing an IC 50 of 9.5 x 10(-9) M. Potency was found to be more than 100-fold higher as compared with antileukoprotease and eglin C.
弹性蛋白酶抑制因子是一种源自人类皮肤的人白细胞弹性蛋白酶抑制剂，已对其针对蛋白酶3（一种中性粒细胞的弹性蛋白降解蛋白酶）的抑制活性进行了测试。将弹性蛋白酶抑制因子的抑制活性与抗白细胞蛋白酶和水蛭素C进行了比较。结果证明，弹性蛋白酶抑制因子是弹性蛋白-异硫氰酸荧光素降解的有效抑制剂，其半数抑制浓度为9.5×10⁻⁹M。与抗白细胞蛋白酶和水蛭素C相比，其效力高出100多倍。
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