Haselwood D M, Castles J J
West J Med. 1977 Sep;127(3):204-14.
Over the past 15 years, many of the elaborate research techniques of cell biology and biochemistry have been applied toward discovering the cause of rheumatoid arthritis. Consequently, it is valuable to review the morphological, physiological and biochemical alterations that have been observed in rheumatoid synovial cells. All of the changes observed suggest that a viral agent may form the basis for these alterations. However, studies to date have failed to isolate or identify the putative causative virus and the search continues.
在过去的15年里，细胞生物学和生物化学的许多精细研究技术都被用于探寻类风湿性关节炎的病因。因此，回顾类风湿性滑膜细胞中观察到的形态、生理和生化改变是很有价值的。所观察到的所有变化都表明，一种病毒因子可能是这些改变的基础。然而，迄今为止的研究未能分离或鉴定出假定的致病病毒，搜索仍在继续。
