Chacaltana Alfonso, Rodríguez Carlos, Urday Carlos, Ramon Walter, Espinoza Julio, Velarde Héctor, Rodríguez Iván, Lucho Elizabeth, Rauch Erick
Hospital General de Huacho.
Rev Gastroenterol Peru. 2009 Jul-Sep;29(3):218-25.
To determine the prevalence and characteristics of premalignant gastric lesions and its relationship with helicobacter pylori infection.
We performed a cross-sectional retrospective study. Between january and june 2008, consecutive subjects of middle and high socioeconomic status were evaluated by upper gastrointestinal endoscopy during a gastric cancer screening in Central FAP Hospital. The demografic, clinic and endoscopic information were analysed.
2616 patients were evaluated. Diagnosis histological of premalignant gastric lesions was made in 187 patients (7.1%) 34 (1.3%) atrophic gastritis (AG), 55 (2.1%), complete intestinal metaplasia (CIM), 92 (3.5%) incomplete intestinal metaplasia (IIM), and 6 (0.2%) dysplasia. The frequency of helicobacter pylori infection was 76.5% (p=0.04), 65.5% (p=NS), 55.4% (p=NS) and 16.7% (p=0.03), in AG, CIM, IIM and dysplasia, respectively. The median age of presentation was similar between the lesions: 53.5 (+/-9.3), 52.6 (+/-11.2), 54.3 (+/-7.8) y 54.2 (+/-12.1) years in AG, CIM, IIM and dysplasia, respectively. The premalignant gastric lesions were more frequent in male subjects and under 60 years (p=NS). There were no significant differences among the differents gastric premalignant lesions and family history of gastric cancer, smoking and alcohol consumption (p=NS). CONCLUSIONS. The prevalence of premalignant gastric lesions in our study was low. The frequency of H. pylori infection was decreased in premalignant lesions more advanced. Association significant was only found among H. pylori infection and AG and dysplasia.
确定癌前胃病变的患病率和特征及其与幽门螺杆菌感染的关系。
我们进行了一项横断面回顾性研究。2008年1月至6月期间，在中央FAP医院的胃癌筛查中，对社会经济地位中高的连续受试者进行了上消化道内镜检查。分析了人口统计学、临床和内镜信息。
共评估了2616例患者。187例（7.1%）患者诊断为癌前胃病变，其中34例（1.3%）为萎缩性胃炎（AG），55例（2.1%）为完全肠化生（CIM），92例（3.5%）为不完全肠化生（IIM），6例（0.2%）为发育异常。AG、CIM、IIM和发育异常中幽门螺杆菌感染率分别为76.5%（p=0.04）、65.5%（p=无统计学意义）、55.4%（p=无统计学意义）和16.7%（p=0.03）。各病变的中位发病年龄相似：AG、CIM、IIM和发育异常分别为53.5（±9.3）、52.6（±11.2）、54.3（±7.8）和54.2（±12.1）岁。癌前胃病变在男性和60岁以下人群中更为常见（p=无统计学意义）。不同的胃癌前病变与胃癌家族史、吸烟和饮酒之间无显著差异（p=无统计学意义）。结论。我们研究中癌前胃病变的患病率较低。在更晚期的癌前病变中，幽门螺杆菌感染率降低。仅在幽门螺杆菌感染与AG和发育异常之间发现显著关联。
