Gopinathannair Rakesh, Olshansky Brian
Division of Cardiovascular Medicine, University of Iowa Hospital, Iowa City, IA 52242, USA.
Indian Pacing Electrophysiol J. 2009 Nov 1;9(6):334-41.
Simple and cost-effective tools that identify patients at increased risk for adverse cardiovascular events are actively sought. High resting sinus heart rate and first degree AV block are easily recognized and commonly encountered findings in a cardiology practice. A growing body of epidemiological and clinical evidence has been shown them to be independent predictors of all-cause and cardiovascular mortality, both in the general population and in patients with structural heart disease. This paper reviews the important role of heart rate and first degree AV block in predicting cardiovascular outcomes, examines the pathophysiological mechanisms underlying this increased risk, and discusses the effectiveness of available therapies to favorably modify these risk factors.
人们一直在积极寻找简单且经济高效的工具，以识别心血管不良事件风险增加的患者。静息窦性心率高和一度房室传导阻滞在心脏病学实践中很容易识别且常见。越来越多的流行病学和临床证据表明，在普通人群和结构性心脏病患者中，它们都是全因死亡率和心血管死亡率的独立预测因素。本文综述了心率和一度房室传导阻滞在预测心血管结局中的重要作用，探讨了这种风险增加背后的病理生理机制，并讨论了现有治疗方法对这些风险因素进行有利调整的有效性。
