Zizi-Sermpetzoglou A, Petrakopoulou N, Tepelenis N, Savvaidou V, Vasilakaki T
Department of Pathology, Tzaneion General Hospital of Pireaus, Pireaus, Greece.
Eur J Gynaecol Oncol. 2009;30(5):586-8.
Primary non-Hodgkin's lymphoma involving the vulva is very rare. It affects predominantly the labia major but it can also present as a clitoral mass or can even be located in the Bartholin's gland. Vulvar lymphoma is an aggressive disease. We describe a case of a 48-year-old woman who presented to our hospital with fever and a slow growing mass in the vulva. She had no other clinical symptoms. CT-scan showed no evidence of disease in any other organ or lymph node tissue. A local excision of the mass followed and the final diagnosis was primary intravascular vulvar lymphoma, of T-cell origin, CD30 positive. In general, intravascular lymphomas are clinically and immunophenotypically heterogenous and may represent more than one entity. They are predominantly of B cell lineage, involving most commonly the skin and rarely other systems or organs. Because of the fact that the vulva is a cutaneous site the development of intravascular lymphoma in this region is possible.
原发性非霍奇金淋巴瘤累及外阴非常罕见。它主要影响大阴唇，但也可表现为阴蒂肿块，甚至可位于巴氏腺。外阴淋巴瘤是一种侵袭性疾病。我们描述了一例48岁女性，她因发热和外阴缓慢生长的肿块前来我院就诊。她没有其他临床症状。CT扫描显示在任何其他器官或淋巴结组织中均无疾病证据。随后对肿块进行了局部切除，最终诊断为原发性血管内外阴淋巴瘤，T细胞起源，CD30阳性。一般来说，血管内淋巴瘤在临床和免疫表型上具有异质性，可能代表不止一种实体。它们主要为B细胞谱系，最常累及皮肤，很少累及其他系统或器官。由于外阴是皮肤部位，该区域有可能发生血管内淋巴瘤。
