功能化醇对金（I）催化的非活化烯烃分子间氢烷氧基化反应效率的增强作用。
Enhancement of reaction efficiency by functionalized alcohols on gold(I)-catalyzed intermolecular hydroalkoxylation of unactivated olefins.
机构信息
Department of Chemistry, Graduate School of Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka, Japan 812-8581, and JST (Japan Science and Technology Agency) CREST, Japan.
出版信息
Org Lett. 2009 Dec 3;11(23):5510-3. doi: 10.1021/ol9023166.
Intermolecular hydroalkoxylation of unactivated olefins catalyzed by the combination of gold(I) and electron deficient phosphine ligands has been developed. Although pairings of unactivated olefins and common aliphatic alcohols gave unsatisfactory results in gold catalyzed hydroalkoxylations, the use of alcohol substrates bearing coordination functionalities such as halogen or alkoxy groups showed great improvement of reactivity.
发展了由金（I）和缺电子膦配体组成的催化剂促进的非活化烯烃的分子间氢烷氧基化反应。尽管在金催化的氢烷氧基化反应中，非活化烯烃和常见脂肪醇的配对反应结果并不令人满意，但使用具有配位官能团（如卤素或烷氧基）的醇底物可以显著提高反应活性。
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