代谢综合征与中国卒中患者颅内大动脉疾病相关。
Metabolic syndrome is associated with intracranial large artery disease among ethnic Chinese patients with stroke.
机构信息
Department of Neurology, Singapore General Hospital Campus, National Neuroscience Institute, Singapore.
出版信息
J Stroke Cerebrovasc Dis. 2009 Nov-Dec;18(6):424-7. doi: 10.1016/j.jstrokecerebrovasdis.2009.01.010.
BACKGROUND
The association of metabolic syndrome (MetS) and intracranial large artery disease (ICLAD) has been described, but only in cohorts of ethnic Korean patients with stroke. We investigated the relationship of MetS and ICLAD among ethnic Chinese patients.
METHODS
This is a prospective study of consecutive ethnic Chinese patients with acute ischemic stroke living in Singapore. ICLAD was diagnosed on transcranial color-coded Doppler or magnetic resonance angiography.
RESULTS
Among the 135 patients studied, the frequency of MetS was higher among patients with ICLAD (39% v 16%, P = .003). This association was independent of age, hypertension, and diabetes (P = .003), and individual MetS criteria (P = .004). The prevalence of ICLAD positively correlated with the number of MetS criteria fulfilled (P = .021).
CONCLUSIONS
Our findings of an association between MetS and ICLAD among ethnic Chinese patients with stroke concur with findings among ethnic Korean patients. This validation provides a basis for further investigation into the pathophysiologic link between MetS and ICLAD.
背景
代谢综合征（MetS）与颅内大动脉疾病（ICLAD）之间存在关联，这在韩国裔卒中患者的队列中已有描述。我们研究了华裔患者中 MetS 和 ICLAD 的关系。
方法
这是一项对居住在新加坡的华裔急性缺血性卒中患者进行的前瞻性研究。采用经颅彩色多普勒或磁共振血管造影诊断 ICLAD。
结果
在 135 名研究患者中，ICLAD 患者的 MetS 发生率更高（39%比 16%，P =.003）。这种关联独立于年龄、高血压和糖尿病（P =.003）以及单个 MetS 标准（P =.004）。ICLAD 的患病率与符合的 MetS 标准数量呈正相关（P =.021）。
结论
我们在华裔卒中患者中发现的 MetS 与 ICLAD 之间的关联与韩国裔患者的研究结果一致。这一验证为进一步研究 MetS 和 ICLAD 之间的病理生理联系提供了依据。
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