Department of Neurosurgery, Qilu Hospital of Shandong University, Jinan 250012, China.
Med Hypotheses. 2010 Mar;74(3):505-7. doi: 10.1016/j.mehy.2009.09.056. Epub 2009 Nov 8.
Trigeminal neuralgia (TN) is an uncommon disorder characterized by recurrent attacks of lancinating pain in the trigeminal nerve distribution. To date, the precise mechanism for TN remains unclear. Among a variety of causes of TN, the microvascular compression (MVC) hypothesis is the most popular one, but controversies still focus on the origin and pathogenesis of the disorder. A number of clinical phenomena still cannot be well explained. We propose a new hypothesis on the pathogenesis of TN - bioresonance. The bioresonance hypothesis states that when the vibration frequency of a structure surrounding the trigeminal nerve becomes close to its natural frequency, the resonance of the trigeminal nerve occurs. The bioresonance can damage trigeminal nerve fibers and lead to the abnormal transmission of the impulse, which may finally result in facial pain. Under the guidance of the bioresonance hypothesis, we hope to explore more non-invasive methods to treat or even cure TN.
三叉神经痛（TN）是一种不常见的疾病，其特征是三叉神经分布区域反复发作的剧烈疼痛。迄今为止，TN 的确切发病机制尚不清楚。在 TN 的多种病因中，微血管压迫（MVC）假说最为流行，但争议仍集中在该疾病的起源和发病机制上。许多临床现象仍无法很好地解释。我们提出了一个关于 TN 发病机制的新假说——生物共振。生物共振假说认为，当围绕三叉神经的结构的振动频率接近其自然频率时，就会发生三叉神经的共振。这种共振会损伤三叉神经纤维，并导致冲动的异常传递，最终可能导致面部疼痛。在生物共振假说的指导下，我们希望探索更多非侵入性的方法来治疗甚至治愈 TN。
