Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.
Int J Antimicrob Agents. 2010 Jan;35(1):25-9. doi: 10.1016/j.ijantimicag.2009.08.020. Epub 2009 Nov 8.
Dalbavancin is an investigational semisynthetic lipoglycopeptide that is structurally related to teicoplanin. We examined the activity of dalbavancin (DAL) compared with tigecycline (TIG), minocycline (MIN), tetracycline (TET), teicoplanin (TEC) and vancomycin (VAN) against community-associated meticillin-resistant Staphylococcus aureus (CA-MRSA) and multidrug-resistant hospital-associated meticillin-resistant S. aureus (MDR HA-MRSA). Two hundred and twenty clinical isolates of CA-MRSA and MDR HA-MRSA were utilised. Minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) were determined according to Clinical and Laboratory Standards Institute guidelines. Selective time-kill studies were performed against CA-MRSA and MDR HA-MRSA in triplicate. Overall, DAL exhibited low MIC values against all strains of MRSA. Time-kill studies with CA-MRSA demonstrated DAL=VAN>TIG>MIN=TEC>TET (P<0.006), and with MDR HA-MRSA demonstrated DAL=VAN=TEC>TIG=MIN>TET (P>0.05). DAL demonstrated potent activity against clinical strains of CA-MRSA and MDR HA-MRSA, including tetracycline-resistant S. aureus.
达巴万星是一种半合成脂糖肽，在结构上与替考拉宁有关。我们研究了达巴万星（DAL）与替加环素（TIG）、米诺环素（MIN）、四环素（TET）、替考拉宁（TEC）和万古霉素（VAN）对社区获得性耐甲氧西林金黄色葡萄球菌（CA-MRSA）和多药耐药医院获得性耐甲氧西林金黄色葡萄球菌（MDR HA-MRSA）的活性。使用了 220 株临床分离的 CA-MRSA 和 MDR HA-MRSA。根据临床和实验室标准协会的指南测定最小抑菌浓度（MIC）和最小杀菌浓度（MBC）。对 CA-MRSA 和 MDR HA-MRSA 进行了三次重复的选择性时间杀伤研究。总体而言，DAL 对所有 MRSA 菌株均表现出低 MIC 值。CA-MRSA 的时间杀伤研究表明 DAL=VAN>TIG>MIN=TEC>TET（P<0.006），MDR HA-MRSA 的时间杀伤研究表明 DAL=VAN=TEC>TIG=MIN>TET（P>0.05）。DAL 对包括四环素耐药金黄色葡萄球菌在内的 CA-MRSA 和 MDR HA-MRSA 临床株表现出强大的活性。
