Clinic of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Germany.
Ann Rheum Dis. 2010 Aug;69(8):1475-8. doi: 10.1136/ard.2009.116475. Epub 2009 Nov 8.
In this pilot study, the effect of sildenafil on digital ulcer (DU) healing and related clinical symptoms was analysed.
A total of 19 patients with systemic sclerosis (SSc) were treated with maximally tolerated sildenafil doses up to 6 months. Primary outcome was the healing of DUs. Changes in other clinical symptoms were also evaluated.
In all, 49 DUs were present at baseline; this decreased to 17 ulcers (p<0.001) at the end of sildenafil treatment. Furthermore, the visual analogue scale (VAS) score for Raynaud's phenomenon (RP), pain and activity improved (p=0.003, p=0.002 and p=0.05, respectively). A total of 9 patients developed 12 new DUs during sildenafil treatment.
This study indicates an effect of sildenafil on DU healing in patients with SSc and an improvement of RP and associated symptoms that should be validated in controlled studies.
在这项初步研究中，分析了西地那非对指溃疡（DU）愈合和相关临床症状的影响。
共有 19 例系统性硬化症（SSc）患者接受了最大耐受剂量的西地那非治疗，时间长达 6 个月。主要结局是 DU 的愈合。还评估了其他临床症状的变化。
基线时共有 49 个 DU，治疗结束时减少到 17 个溃疡（p<0.001）。此外，雷纳德现象（RP）、疼痛和活动的视觉模拟量表（VAS）评分均有改善（p=0.003、p=0.002 和 p=0.05）。共有 9 例患者在西地那非治疗期间出现了 12 个新的 DU。
本研究表明西地那非对 SSc 患者的 DU 愈合有作用，并改善了 RP 及其相关症状，这需要在对照研究中进一步验证。
Zotero 插件