Friedrichson E, Rehberger P, Fuhrmann J T, Walz F, Meurer M, Pfeiffer C
Klinik und Poliklinik für Dermatologie, Medizinische Fakultät der Technischen Universität Dresden, Dresden.
Hautarzt. 2008 Mar;59(3):230-2. doi: 10.1007/s00105-007-1366-1.
Acral ulcers in patients with progressive systemic sclerosis (PSS) are often recalcitrant to therapy. Sildenafil, an inhibitor of phosphodiesterase-5, dilates small arteries by increasing endothelial cGMP. Oral administration of sildenafil to a 35-year-old white male patient suffering from incapacitating PSS with severe pulmonary arterial hypertension and acral ulcers induced a clinically significant reduction in dyspnea and increase in walking distance within one week as well as complete and long-lasting healing of all ulcers within five weeks. This case demonstrates the efficacy of sildenafil in the treatment of scleroderma-associated refractory acral ulcers.
进行性系统性硬化症（PSS）患者的肢端溃疡往往对治疗反应不佳。西地那非是一种磷酸二酯酶-5抑制剂，通过增加内皮细胞环磷酸鸟苷（cGMP）来扩张小动脉。对一名35岁患有严重肺动脉高压和肢端溃疡的失能性PSS白人男性患者口服西地那非，一周内呼吸困难得到临床显著改善，步行距离增加，五周内所有溃疡完全愈合且愈合持久。该病例证明了西地那非治疗硬皮病相关难治性肢端溃疡的疗效。
