Department of Pediatrics, Division of Immunology and Transplantation Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Infect Immun. 2010 Jan;78(1):32-8. doi: 10.1128/IAI.00929-09. Epub 2009 Nov 9.
Lineage-specific responses from the effector T-cell repertoire form a critical component of adaptive immunity. The recent identification of Th17 cells-a third, distinct lineage of helper T cells-collapses the long-accepted paradigm in which Th1 and Th2 cells distinctly mediate cellular and humoral immunity, respectively. In this minireview, we discuss the involvement of the Th17 lineage during infection by extracellular bacteria, intracellular bacteria, and fungi. Emerging trends suggest that the Th17 population bridges innate and adaptive immunity to produce a robust antimicrobial inflammatory response. However, because Th17 cells mediate both host defense and pathological inflammation, elucidation of mechanisms that attenuate but do not completely abolish the Th17 response may have powerful implications for therapy.
效应 T 细胞库的谱系特异性反应构成适应性免疫的关键组成部分。最近鉴定的 Th17 细胞——辅助 T 细胞的第三个独特谱系——推翻了长期以来的观点，即 Th1 和 Th2 细胞分别介导细胞和体液免疫。在这篇综述中，我们讨论了 Th17 谱系在胞外细菌、胞内细菌和真菌感染期间的参与。新兴趋势表明，Th17 群体连接先天免疫和适应性免疫，产生强大的抗微生物炎症反应。然而，由于 Th17 细胞介导宿主防御和病理性炎症，阐明减轻但不完全消除 Th17 反应的机制可能对治疗具有重要意义。
