Ou Yvonne, Yu Fei, Law Simon K, Coleman Anne L, Caprioli Joseph
Glaucoma Division, Jules Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Arch Ophthalmol. 2009 Nov;127(11):1436-41. doi: 10.1001/archophthalmol.2009.267.
To evaluate the long-term efficacy of intraocular pressure reduction and complications of Ahmed glaucoma valve (AGV) implantation in children with primary congenital glaucoma.
The medical records of patients with primary congenital glaucoma who underwent AGV implantation with a minimum follow-up of 6 months were reviewed. The primary outcome measure was cumulative probability of success, defined as intraocular pressure greater than 5 mm Hg and less than 23 mm Hg and at least a 15% reduction from the preoperative intraocular pressure, without serious complications, additional glaucoma surgery, or loss of light perception.
Thirty eyes of 19 children with primary congenital glaucoma who underwent AGV implantation with a minimum follow-up of 6 months were reviewed. The children had a mean (SD) age of 1.8 (2.6) years, a mean (SD) preoperative intraocular pressure of 28.4 (6.7) mm Hg, and a mean (SD) follow-up time of 57.6 (48.0) months. The cumulative probability of success was 63% in 1 year and 33% in 5 years. After a second AGV implantation, the cumulative probability of success was 86% in 1 and 2 years and 69% in 5 years. Hispanic ethnicity (P = .02) and being female (P = .005) were associated with increased risk of failure.
Thirty-three percent of AGV implantations in children with primary congenital glaucoma were successful after 5 years of follow-up. With the implantation of a second AGV, the 5-year success rate increased to 69%.
评估艾哈迈德青光眼阀（AGV）植入术降低原发性先天性青光眼患儿眼压的长期疗效及并发症。
回顾性分析接受AGV植入术且随访至少6个月的原发性先天性青光眼患者的病历。主要观察指标为成功的累积概率，定义为眼压大于5 mmHg且小于23 mmHg，较术前眼压至少降低15%，无严重并发症、额外青光眼手术或无光感丧失。
回顾性分析19例接受AGV植入术且随访至少6个月的原发性先天性青光眼患儿的30只眼。患儿平均（标准差）年龄为1.8（2.6）岁，术前平均（标准差）眼压为28.4（6.7）mmHg，平均（标准差）随访时间为57.6（48.0）个月。1年时成功的累积概率为63%，5年时为33%。二次AGV植入术后，1年和2年时成功的累积概率为86%，5年时为69%。西班牙裔（P = .02）和女性（P = .005）与失败风险增加相关。
原发性先天性青光眼患儿AGV植入术后5年随访，33%的植入术成功。二次AGV植入后，5年成功率提高至69%。
