Department of Psychiatry, VU University Medical Center, A.J. Ernst Street 887, Amsterdam, Netherlands.
Curr Opin Psychiatry. 2010 Jan;23(1):8-11. doi: 10.1097/YCO.0b013e328333e17f.
Although most would agree that to prevent is better than to cure, prevention of depression has only recently been studied rigorously. The purpose of the present study is to review the state of the current literature.
The technical and theoretical literature underpinning depression prevention is developing in concert with high-quality intervention studies testing the effects of novel preventive interventions. Data suggest that universal prevention, targeting the whole population, is not likely to be effective, whereas both selective (high-risk groups) and indicated (people with some signs or symptoms, but no disorder) prevention may be very effective. Overall, preventive interventions may reduce the onset of depression by as much as 25-50%, which compares favourably with treatment.
Preventing depression may be effective at all ages and in diverse settings. Prevention has moved beyond the stage of pioneering studies and it deserves a regular place within our armamentarium to combat depression.
尽管大多数人都认为预防胜于治疗，但直到最近，人们才开始严谨地研究预防抑郁症。本研究旨在综述目前的文献现状。
抑郁症预防的技术和理论文献与高质量干预研究同步发展，这些研究检验了新型预防干预措施的效果。数据表明，针对整个人群的普遍预防不太可能有效，而选择性（高危人群）和指示性（有一些迹象或症状，但没有障碍的人）预防可能非常有效。总的来说，预防干预措施可能使抑郁症的发病减少 25-50%，这与治疗效果相当。
预防抑郁症在各个年龄段和不同环境中都可能有效。预防已经超越了开拓性研究的阶段，它应该在我们对抗抑郁症的武器库中占有一席之地。
