Allart-van Dam E, Hosman C M H, Hoogduin C A L, Schaap C P D R
Department of Clinical Psychology and Personality Psychology, University of Nijmegen, The Netherlands.
J Affect Disord. 2007 Jan;97(1-3):219-28. doi: 10.1016/j.jad.2006.06.020. Epub 2006 Jul 24.
People with subclinical depressive symptoms are at increased risk of depressive disorder, little is known on the prevention of depressive disorder in this population. This study evaluates the long-term preventive effects of an effective depression treatment, the Coping with Depression (CWD) course. This paper describes the effect of the CWD course on the incidence of depressive episodes and depressive symptoms, and explores whether the initial level of symptoms and gender has differential intervention effects.
Participants (N=104) were adults with subclinical depressive symptoms, who were randomly assigned to either a preventive group course condition, the 'Coping with Depression' course, or to an assessment-and-advice-only control group condition. Follow-up results were measured 6 and 12 months after completion of the course.
The CWD course showed to be effective in preventing depressive symptomatology but there was no evidence that the course prevented depressive disorder. 25% of the control group and 27.3% of the course group developed a depressive disorder within a year. Initial depressive symptomatology moderated the outcomes: only participants with low initial symptomatology appeared to benefit in the long term from course participation.
The CWD course is effective as a treatment for subclinical depression. Preventive effects are restricted to participants with initially low depression levels. Therefore, this subgroup should be targeted in future depression-prevention practices and in future prevention studies.
有亚临床抑郁症状的人群患抑郁症的风险增加，对于该人群抑郁症的预防知之甚少。本研究评估了一种有效的抑郁症治疗方法——应对抑郁症（CWD）课程的长期预防效果。本文描述了CWD课程对抑郁发作和抑郁症状发生率的影响，并探讨症状的初始水平和性别是否具有不同的干预效果。
参与者（N = 104）为有亚临床抑郁症状的成年人，他们被随机分配到预防组课程条件下，即“应对抑郁症”课程，或仅接受评估和建议的对照组条件下。在课程结束后6个月和12个月测量随访结果。
CWD课程在预防抑郁症状方面显示出有效性，但没有证据表明该课程能预防抑郁症。对照组中有25%的人以及课程组中有27.3%的人在一年内患上了抑郁症。初始抑郁症状调节了结果：只有初始症状较轻的参与者似乎从课程参与中获得了长期益处。
CWD课程作为亚临床抑郁症的一种治疗方法是有效的。预防效果仅限于初始抑郁水平较低的参与者。因此，在未来的抑郁症预防实践和预防研究中应针对这一亚组人群。
