The National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.
Epidemiology. 2010 Jan;21(1):114-7. doi: 10.1097/EDE.0b013e3181c04dcf.
Delivery of a boy has been reported to increase a woman's risk of recurrent miscarriage in subsequent pregnancies. We explored whether delivery of boys similarly increases the risk of a subsequent stillbirth.
We identified all Danish women delivering their first child (singleton) between 1980 and 1998 (n = 499,731) using the Danish Birth Registry. These women had subsequent singleton births through 2004 (n = 558,314). We assessed the risk of stillbirth conditional on sex of prior children.
The risk of stillbirth was increased by 12% after deliver of boys compared with girls (relative risk = 1.12 [95% confidence interval = 1.02-1.23]). This association did not appear to be explained by maternal confounders.
Stillbirth risk appears to be slightly higher among the pregnancies of women who have previously delivered a boy. One possible mechanism is maternal immune response to male-specific minor histocompatibility antigens initiated during pregnancies with boys.
已有报道称，分娩男孩会增加女性随后妊娠中反复流产的风险。我们探讨了分娩男孩是否同样会增加随后死胎的风险。
我们利用丹麦出生登记处，确定了 1980 年至 1998 年间分娩第一胎（单胎）的所有丹麦女性（n=499731）。这些女性在 2004 年前又生育了单胎（n=558314）。我们根据先前孩子的性别评估了死胎的风险。
与分娩女孩相比，分娩男孩后死胎的风险增加了 12%（相对风险=1.12[95%置信区间：1.02-1.23]）。这种关联似乎不是由母体混杂因素引起的。
与分娩女孩的妊娠相比，先前分娩男孩的妊娠中死胎的风险似乎略高。一种可能的机制是母体对男性特异性次要组织相容性抗原的免疫反应，这种反应在怀有男孩的妊娠中被启动。
