Rout Ronnaly, Mohapatra Biranchi Narayana, Kar Shantanu Kumar, Ranjit Manoranjan
Regional Medical Research Centre (ICMR), Bhubaneswar-751023, Orissa, India.
Trop Biomed. 2009 Aug;26(2):165-72.
Heterogeneity in parasite virulence has been proposed to be one of the several factors that contribute to the wide spectrum of disease severity in Plasmodium falciparum malaria. In the present study, we have attempted to determine the association of multiple genotype infection (MGI) and /or any specific genotype with the severity of P. falciparum malaria. Analysis of two highly polymorphic regions of the merozoite surface protein (MSP1 and MSP2) and three microsatellite loci (MS) have shown a strong association between multiple genotype infection (MGI) and severe P. falciparum malaria. Evidence for stratification of the parasite population in to differing virulence has been found .The evolution of such parasite virulence has been discussed in the light of kin and group selection model.
寄生虫毒力的异质性被认为是导致恶性疟原虫疟疾疾病严重程度范围广泛的几个因素之一。在本研究中，我们试图确定多重基因型感染（MGI）和/或任何特定基因型与恶性疟原虫疟疾严重程度之间的关联。对裂殖子表面蛋白的两个高度多态性区域（MSP1和MSP2）以及三个微卫星位点（MS）的分析表明，多重基因型感染（MGI）与严重的恶性疟原虫疟疾之间存在密切关联。已发现将寄生虫群体分层为不同毒力的证据。已根据亲缘和群体选择模型讨论了这种寄生虫毒力的演变。
