急性实验性内毒素血症中甲状腺功能活性与促炎和免疫调节细胞因子水平的关系
Relationship between functional activity of the thyroid gland and levels of proinflammatory and immunoregulatory cytokines in acute experimental endotoxicosis.
作者信息
Yaglova N V
机构信息
Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia.
出版信息
Bull Exp Biol Med. 2009 Jun;147(6):698-700. doi: 10.1007/s10517-009-0603-2.
PMID:19902060
Abstract
Functional activity of the thyroid gland is reduced in Wistar rats with acute experimental endotoxicosis developing in response to sublethal dose of LPS and paralleled by polarization of the immune response by the Th-1 type. This decrease does not depend on the level of thyrotropic hormone and correlates with the production of IL-2 and IFN-gamma.
摘要
在因亚致死剂量脂多糖引发急性实验性内毒素血症并伴有Th-1型免疫反应极化的Wistar大鼠中，甲状腺的功能活性降低。这种降低不依赖于促甲状腺激素水平，且与白细胞介素-2和γ-干扰素的产生相关。
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