[Thyroid morphofunctional changes in acute experimental endotoxicosis in rats].

The aim of the study was to investigate morphofunctional changes in the thyroid and its hormonal status of Wistar rats with non-thyroid illnesses caused by acute endotoxicosis. The latter was simulated, by administering the sublethal dose of lipopolysaccharide. Thyroid morphological and morphometric studies on disease days 1 and 7 established that the earliest sign of non-thyroid illnesses was the dissociation of synthetic processes and thyroglobulin release into the lumen of a follicle and its resorption, i.e. desynchronization of the phases of a cell secretory cycle and dissociation of the directionality of morphodynamic processes in the central and peripheral zones of thyroid lobes. Recovery of the unidirectionality of these processes may be interpreted as a sign that suggests the regression of non-thyroid illnesses.