de Micheli Alfredo, Pastelín Gustavo, Chávez Domínguez Rafael, Iturralde Torres Pedro, Medrano Gustavo A
Instituto Nacional de Cardiología lgnacio Chávez, México.
Arch Cardiol Mex. 2009 Jul-Sep;79(3):175-81.
To study the possible action of inosine on experimental ventricular tachyarrhythmias.
We used 92 mongrel dogs weighing 13 kg-17 kg, anesthetized with 30 mg/kg sodium pentobarbital applied intravenously. Myocardial lesions were induced by injecting 1 ml-1.5 ml of 70% phenol in the free wall of the left ventricle. In 36 dogs, the ventricular arrhythmia (VT) was induced 30 min later with aconitine crystals inserted into the periphery of the damaged area; in 16, VT was due only to myocardial damage and in the other 13 VT was spontaneously originated. Twenty-nine animals constituted the control group; no inosine was administered to them. The possible effects of inosine were studied in 63 animals. Leads II, aVR or aVL, right and Left unipolar intraventricular leads and that on the wall of the superior vena cava were recorded under control conditions, once the myocardial damage had been induced, during the ventricular tachycardia, and following the injection of inosine. Of the 63 inosine-treated animals; in 34, VT was due to aconitine; in 16, it was produced only by the myocardial damage and, in 13, VT was presented spontaneously.
Sinus rhythm was not reestablished in the animals of the control group. Inosine reestablished the sinus rhythm in 26 of 34 dogs (76%) that received phenol and aconitine, in 13 of the 16 (81%) presenting only the myocardial damage, and in 6 of the 13 (46%) with spontaneous ventricular tachycardia. In some experiments, inosine induced supraventricular tachycardias, ventricular-atrial blocks, and ventricular pre-excitation phenomena.
In this experimental series, inosine showed antiarrhythmic and arrhythmogenic effects, similar to those of adenosine from which it derives.
研究肌苷对实验性室性心律失常的可能作用。
我们使用了92只体重13千克至17千克的杂种犬，通过静脉注射30毫克/千克戊巴比妥钠进行麻醉。通过在左心室游离壁注射1毫升至1.5毫升70%苯酚诱导心肌损伤。在36只犬中，30分钟后将乌头碱晶体插入受损区域周边诱导室性心律失常（VT）；16只犬的VT仅由心肌损伤引起，另外13只犬的VT是自发产生的。29只动物组成对照组，未对其给予肌苷。在63只动物中研究了肌苷的可能作用。在对照条件下、诱导心肌损伤后、室性心动过速期间以及注射肌苷后，记录II导联、aVR或aVL导联、右和左单极心室内导联以及上腔静脉壁导联。在63只接受肌苷治疗的动物中，34只犬的VT由乌头碱引起，16只仅由心肌损伤产生，13只自发出现VT。
对照组动物未恢复窦性心律。在接受苯酚和乌头碱的34只犬中，26只（76%）的肌苷恢复了窦性心律；在仅表现心肌损伤的16只犬中，13只（81%）恢复了窦性心律；在自发室性心动过速的13只犬中，6只（46%）恢复了窦性心律。在一些实验中，肌苷诱发了室上性心动过速、室房传导阻滞和心室预激现象。
在这个实验系列中，肌苷显示出抗心律失常和致心律失常作用，类似于其衍生而来的腺苷的作用。
