Advanced Centre for Biochemical Engineering, University College London, London, UK.
Regen Med. 2009 Nov;4(6):835-53. doi: 10.2217/rme.09.64.
The advantages and disadvantages of autologous and allogeneic human cells for regenerative medicine are summarized. The comparison of relative advantages includes: ease and cost of treating large numbers of patients, the speed of availability of therapy and the differing complexity of the development pathways. The comparison of relative disadvantages deals with issues such as variability of source material, the risks of cell abnormality and of viral and prion contamination, and the sensitive issues surrounding use of embryo-derived cells. From the comparisons, several potentially decisive issues are drawn out, such as possible immune response and teratoma formation, the impact of patents and the virtues of hospital versus industry-centered development.
总结了用于再生医学的自体和同种异体人类细胞的优缺点。相对优势的比较包括：治疗大量患者的难易程度和成本、治疗方法的可用性速度以及开发途径的复杂程度不同。相对劣势的比较涉及到诸如来源材料的可变性、细胞异常和病毒及朊病毒污染的风险以及围绕胚胎来源细胞使用的敏感问题等问题。通过比较，得出了几个潜在的决定性问题，例如可能的免疫反应和畸胎瘤形成、专利的影响以及医院与工业为中心的发展的优点。
