对映贝壳杉烯酸类似物：它们的化学合成与生物活性。

Nordihydroguaiaretic acid analogues: their chemical synthesis and biological activities.

机构信息

School of Pharmaceutical Sciences, Sun Yat-sen University, 132 East Circle at University City Guangzhou, China 510006.

出版信息

Curr Top Med Chem. 2009;9(17):1636-59. doi: 10.2174/156802609789941915.

DOI:10.2174/156802609789941915

PMID:19903157

Abstract

Nordihydroguaiaretic acid is a natural occurring lignan mainly isolated and commercially produced from desert plant, creosote bush (Larrea divaricata Cav. Or Corillea tridentate), which can be widely found in the border zone of southern of USA and northern of Mexico. During past 100 years, extensive research has demonstrated that nordihydroguaiaretic acid and its synthetic analogues are potentially useful in treating diseases related to cancers, diabetes, viral, bacterial infections, and inflammation. Remarkably, terameprocol, a tetra-O-methyl derivative of nordihydroguaiaretic acid, is currently in Phase I/II clinical trials as an anticancer agent. This review deals with the chemical synthesis and bioactivities of nordihydroguaiaretic acid and its structurally-related derivatives, which possess anticancer, antioxidant, antimicrobial, anti-inflammatory and immunosuppressive activities. The review consists of the data reported in over 100 publications.

摘要

对映贝壳杉烯酸是一种天然存在的木脂素，主要从沙漠植物（Larrea divaricata Cav. 或 Corillea tridentate）中分离和商业化生产，这种植物在美国南部和墨西哥北部的边境地区广泛存在。在过去的 100 年里，广泛的研究表明，对映贝壳杉烯酸及其合成类似物在治疗与癌症、糖尿病、病毒、细菌感染和炎症相关的疾病方面具有潜在的用途。值得注意的是，terameprocol，对映贝壳杉烯酸的四-O-甲基衍生物，目前正在进行 I/II 期临床试验，作为一种抗癌药物。本综述涉及对映贝壳杉烯酸及其结构相关衍生物的化学合成和生物活性，这些衍生物具有抗癌、抗氧化、抗菌、抗炎和免疫抑制活性。综述包括了超过 100 篇出版物中报道的数据。