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在自由活动的大鼠的苔藓纤维-CA3 突触处，频率易化通过一种由腺苷 A1 受体调节的机制促进持久 LTD 的诱导。

Frequency facilitation at mossy fiber-CA3 synapses of freely behaving rats contributes to the induction of persistent LTD via an adenosine-A1 receptor-regulated mechanism.

机构信息

Department of Experimental Neurophysiology, Medical Faculty, Ruhr University Bochum, 44780 Bochum, Germany.

出版信息

Cereb Cortex. 2010 May;20(5):1121-30. doi: 10.1093/cercor/bhp184. Epub 2009 Nov 10.

DOI:10.1093/cercor/bhp184
PMID:19903765
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2852506/
Abstract

Frequency facilitation (FF), comprising a rapid and multiple-fold increase in the magnitude of evoked field potentials, is elicited by low-frequency stimulation (LFS) at mossy fiber-CA3 synapses. Here, we show that in freely behaving rats, FF reliably occurs in response to 1 and 2Hz but not in response to 0.25-, 0.3-, or 0.5-Hz LFS. Strikingly, prolonged (approximately 600 s) FF was tightly correlated to the induction of long-term depression (LTD) in freely moving animals. Although LFS at 2 Hz elicited unstable FF and unstable LTD, application of LFS at 1 Hz elicited pronounced FF, as well as robust LTD that persisted for over 24 h. This correlation of prolonged FF with LTD was absent at stimulation frequencies that did not induce FF. The adenosine-A1 receptor appears to participate in these effects: Application of adenosine-A1, but not adenosine-A3, receptor antagonists enhanced mossy fiber synaptic transmission and occluded FF. Furthermore, adenosine-A1 receptor antagonism resulted in more stable FF at 1 or 2 Hz and elicited more potent LTD. These data support the fact that FF contributes to the enablement of long-term information storage at mossy fiber-CA3 synapses and that the adenosine-A1 receptor may regulate the thresholds for this process.

摘要

频率易化（FF），由低频刺激（LFS）在苔藓纤维-CA3 突触引起的诱发电场潜力的快速和多倍增加组成。在这里，我们表明，在自由活动的大鼠中，1Hz 和 2Hz 的 LFS 可靠地引起 FF，但 0.25Hz、0.3Hz 或 0.5Hz 的 LFS 则不会引起 FF。引人注目的是，延长（约 600s）FF 与自由活动动物中长时程抑制（LTD）的诱导密切相关。虽然 2Hz 的 LFS 引起不稳定的 FF 和不稳定的 LTD，但 1Hz 的 LFS 引起明显的 FF，以及持续超过 24 小时的强大 LTD。在不引起 FF 的刺激频率下，延长的 FF 与 LTD 之间没有这种相关性。腺苷 A1 受体似乎参与了这些效应：应用腺苷 A1 而非腺苷 A3 受体拮抗剂增强了苔藓纤维突触传递并阻断了 FF。此外，腺苷 A1 受体拮抗剂在 1 或 2Hz 时导致更稳定的 FF，并引发更强的 LTD。这些数据支持 FF 有助于在苔藓纤维-CA3 突触中实现长期信息存储的事实，并且腺苷 A1 受体可能调节该过程的阈值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8714/2852506/a45382f81f4b/cercorbhp184f07_lw.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8714/2852506/8c05c359ba0c/cercorbhp184f01_ht.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8714/2852506/5b2532e75cbc/cercorbhp184f02_ht.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8714/2852506/7574f9ab0c3d/cercorbhp184f03_ht.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8714/2852506/f28c51bea245/cercorbhp184f04_ht.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8714/2852506/d40fe49eadc6/cercorbhp184f05_lw.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8714/2852506/d6f2ff191f00/cercorbhp184f06_lw.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8714/2852506/a45382f81f4b/cercorbhp184f07_lw.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8714/2852506/8c05c359ba0c/cercorbhp184f01_ht.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8714/2852506/5b2532e75cbc/cercorbhp184f02_ht.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8714/2852506/7574f9ab0c3d/cercorbhp184f03_ht.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8714/2852506/f28c51bea245/cercorbhp184f04_ht.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8714/2852506/d40fe49eadc6/cercorbhp184f05_lw.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8714/2852506/d6f2ff191f00/cercorbhp184f06_lw.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8714/2852506/a45382f81f4b/cercorbhp184f07_lw.jpg

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