CEA, LETI, MINATEC, 17 rue des Martyrs, F-38054 Grenoble, France.
Phys Med Biol. 2009 Dec 7;54(23):7107-19. doi: 10.1088/0031-9155/54/23/005. Epub 2009 Nov 11.
This paper addresses the inverse problem of time-resolved (fluorescence) diffuse optical tomography from temporal moments of the measurements. A methodology that enables one to provide fairly comparable reconstructions is presented. The proposed reconstruction methodology is applied to infinite medium synthetic phantoms in the transmission geometry. Reconstructions are performed for moment orders increasing from 0 to 3. The reconstruction quality is shown to be increasing when higher moment orders are added. However, the value of the highest useful moments order strongly depends on the number of photons that can be acquired. In particular, it can be considered that the benefit of using higher order moments vanishes when fewer than 10(8) photons are detected. The evolution of the reconstruction quality with respect to the optical properties of the medium and fluorescence lifetime is also shown.
本文针对时间分辨（荧光）漫射光学层析成像从测量的时间瞬间的逆问题。提出了一种能够提供相当可比重建的方法。所提出的重建方法应用于传输几何中的无限介质合成幻影。对于从 0 到 3 的阶数进行重建。当添加更高阶时，重建质量显示出增加的趋势。然而，最高有用阶数的价值强烈取决于可以获取的光子数量。具体而言，可以认为当检测到少于 10(8)个光子时，使用更高阶矩的好处消失。还显示了重建质量随介质光学性质和荧光寿命的演变。
