Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT, UK.
Phys Med Biol. 2009 Dec 7;54(23):7045-61. doi: 10.1088/0031-9155/54/23/001. Epub 2009 Nov 11.
Volumetric modulated arc therapy (VMAT) offers a challenge to classical dosimetry protocols as the beams are dynamic in orientation and aperture shape and may include small apertures. The aim of this paper is to apply a formalism to VMAT beams that has recently been published by the International Atomic Energy Agency (IAEA) working party to improve the dosimetry for small and non-standard fields. We investigated three possible fields and assessed their suitability as plan class specific reference (pcsr) fields. The factors in the new dosimetry formalism were investigated: the conversion of dose to water from the conventional reference field to the pcsr and then from the pcsr to a treatment plan, using a PTW semiflex chamber, two Farmer chambers and an electron diode. Finally, the dose was compared for Alanine, the new formalism and calculated using Pinnacle(3) (Philips Radiation Oncology Systems) for two typical clinical VMAT beams. Correction factors between the reference field and the pcsr determined with Alanine range from 0.1% to 2.3% for the three pcsr fields. Dose to water measured using the calibrated ionization chambers is less than 2% different to the dose calculated by Pinnacle(3). VMAT planning and delivery procedures have been successfully implemented and a new dosimetry protocol has been investigated for this new technique. Calibration factors for pcsr fields are found to be up to 2.3% different when using the new formalism, compared to using a standard dosimetry protocol. Using the calibration factors determined in the pcsr fields, the ionization chambers and electron diode agree to within 1% with Alanine dosimetry for two clinical VMAT plans. Good agreements between calculations and measurements are found for these two plans when the new formalism is used.
容积旋转调强放疗(VMAT)对经典剂量学协议提出了挑战,因为射束在方向和孔径形状上是动态的,并且可能包括小孔径。本文的目的是应用一种形式主义来处理最近由国际原子能机构(IAEA)工作组发布的 VMAT 射束,以改善小和非标准野的剂量学。我们研究了三个可能的射束,并评估了它们作为计划类特定参考(pcsr)射束的适用性。研究了新剂量学形式主义中的因素:从常规参考射束到 pcsr 的剂量向水的转换,然后从 pcsr 到治疗计划,使用 PTW 半柔性腔、两个 Farmer 腔和电子二极管。最后,使用 Alanine、新形式主义和使用 Philips Radiation Oncology Systems 的 Pinnacle(3) 为两个典型的临床 VMAT 射束比较了剂量。使用 Alanine 确定的参考射束和 pcsr 之间的校正因子对于三个 pcsr 射束在 0.1%到 2.3%之间变化。使用校准电离室测量的水剂量与 Pinnacle(3) 计算的剂量相差不超过 2%。已经成功实施了 VMAT 计划和交付程序,并针对这项新技术研究了新的剂量学协议。与使用标准剂量学协议相比,当使用新形式主义时,pcsr 射束的校准因子差异高达 2.3%。在 pcsr 射束中确定校准因子后,电离室和电子二极管与 Alanine 剂量学在两个临床 VMAT 计划中一致,差异在 1%以内。当使用新形式主义时,这两个计划的计算和测量之间存在良好的一致性。