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利用原子力显微镜原位、实时跟踪抗分枝杆菌药物处理的分枝杆菌 JLS 的细胞壁形貌和纳米力学特性。

In situ, real-time tracking of cell wall topography and nanomechanics of antimycobacterial drugs treated Mycobacterium JLS using atomic force microscopy.

机构信息

Biological Engineering Program, Utah State University, 4105 Old Main Hill, Logan, Utah 84322-4105, USA.

出版信息

Chem Commun (Camb). 2009 Dec 7(45):7021-3. doi: 10.1039/b914605a. Epub 2009 Oct 9.

DOI:10.1039/b914605a
PMID:19904381
Abstract

Two antimycobacterial drugs ethambutol (EMB) and isoniazid (INH) were found to result in decreases of biomechanical properties including adhesion force, cell wall spring constant, and Young's modulus in Mycobacterium sp. strain JLS (M. JLS).

摘要

两种抗分枝杆菌药物乙胺丁醇（EMB）和异烟肼（INH）被发现导致分枝杆菌 JLS 株（M. JLS）的生物力学特性下降，包括粘附力、细胞壁弹性常数和杨氏模量。

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