Cybulsky M I, Gimbrone M A
Department of Pathology, Brigham and Women's Hospital, Boston, MA.
Science. 1991 Feb 15;251(4995):788-91. doi: 10.1126/science.1990440.
An inducible rabbit endothelial adhesion molecule that is selective for mononuclear leukocytes has been identified. This adhesion protein was expressed on the surface of activated cultured endothelium in two forms, 118 and 98 kilodaltons, the amino-terminal sequence of each being highly homologous to human VCAM-1. In dietary hypercholesterolemic and Watanabe heritable hyperlipidemic rabbit models of atherosclerosis, this adhesion molecule was found to be expressed in a localized fashion by aortic endothelium that overlies early foam cell lesions. This lesion-localized expression suggests a potential endothelium-dependent mechanism for mononuclear leukocyte recruitment during atherogenesis and may provide a molecular marker for early atherosclerosis.
已鉴定出一种对单核白细胞具有选择性的可诱导兔内皮粘附分子。这种粘附蛋白以两种形式表达于活化的培养内皮细胞表面，分子量分别为118和98千道尔顿，每种形式的氨基末端序列与人血管细胞粘附分子-1高度同源。在饮食性高胆固醇血症和渡边遗传性高脂血症兔动脉粥样硬化模型中，发现这种粘附分子由覆盖早期泡沫细胞病变的主动脉内皮以局部化方式表达。这种病变局部化表达提示了动脉粥样硬化形成过程中单核白细胞募集的潜在内皮依赖性机制，并可能为早期动脉粥样硬化提供一种分子标志物。
