Department of Experimental Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Biofactors. 2009 Nov-Dec;35(6):474-83. doi: 10.1002/biof.62.
CD40, a transmembrane receptor of the tumor necrosis factor gene superfamily is expressed on a variety of cells, such as monocytes, B-cells, antigen presenting cells, endothelial, smooth muscle cells, and fibroblasts. The interaction between CD40 and CD40 ligand (CD40L) enhances the expression of cytokines, chemokines, matrix metalloproteinases, growth factors, and adhesion molecules, mainly through the stimulation of nuclear factor kappa B. The aim of this review is to summarize the molecular and cellular characteristics of CD40 and CD40L, the mechanisms that regulate their expression, the cellular responses they stimulate and finally their implication in the pathophysiology of inflammatory and autoimmune diseases.
CD40 是肿瘤坏死因子基因超家族的一种跨膜受体，表达于多种细胞上，如单核细胞、B 细胞、抗原呈递细胞、内皮细胞、平滑肌细胞和成纤维细胞。CD40 与 CD40 配体（CD40L）之间的相互作用增强了细胞因子、趋化因子、基质金属蛋白酶、生长因子和黏附分子的表达，主要通过核因子 κB 的刺激来实现。本文综述了 CD40 和 CD40L 的分子和细胞特征、调节其表达的机制、它们所刺激的细胞反应以及它们在炎症和自身免疫性疾病病理生理学中的意义。
