将λ噬菌体诱导模拟为裂解抑制的协同失效模式。
Lambda-prophage induction modeled as a cooperative failure mode of lytic repression.
作者信息
Chia Nicholas, Golding Ido, Goldenfeld Nigel
机构信息
Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 1206 West Gregory Drive, Urbana, Illinois 61801, USA.
出版信息
Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Sep;80(3 Pt 1):030901. doi: 10.1103/PhysRevE.80.030901. Epub 2009 Sep 1.
Abstract
We analyze a system-level model for lytic repression of lambda phage in E. coli using reliability theory, showing that the repressor circuit comprises four redundant components whose failure mode is prophage induction. Our model reflects the specific biochemical mechanisms involved in regulation, including long-range cooperative binding, and its detailed predictions for prophage induction in E. coli under ultraviolet radiation are in good agreement with experimental data.
摘要
我们使用可靠性理论分析了大肠杆菌中λ噬菌体裂解抑制的系统级模型，结果表明阻遏物回路由四个冗余组件组成，其失效模式是原噬菌体诱导。我们的模型反映了调控过程中涉及的特定生化机制，包括长程协同结合，并且其对大肠杆菌在紫外线辐射下原噬菌体诱导的详细预测与实验数据高度吻合。
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