Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands.
Microcirculation. 2009 Nov;16(8):714-24. doi: 10.3109/10739680903199186.
Hyper- and hypoestrogenism that persist for a long time can affect vascular and metabolic function. However, it is not clear whether the same is true for subtle sex hormone changes (i.e., during the menstrual cycle).
Twenty-one healthy normal-weight women with regular cycles were studied during the early-follicular (day 3 +/- 2), late-follicular (day 12 +/- 2), and midluteal (day 20 +/- 3) phases. Microvascular function was assessed by skin iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP), by skin-capillary recruitment after arterial and venous occlusion (i.e., capillaroscopy), and by Fourier analysis of resting skin laser Doppler flow at rest (i.e., vasomotion). Insulin sensitivity (i.e., homeostasis model assessment) and blood pressure were also determined during the study days.
Three women were excluded from analyses because they were anovulatory. Skin microvascular responses to ACh and SNP, capillary function, vasomotion, insulin sensitivity, and blood pressure did not differ between the three phases (P > or = 0.1). Further, microvascular function did not correlate with plasma-estrogen levels (r = -0.06-0.2; P> or = 0.2).
Microvascular function does not demonstrate a clear menstrual-cycle-dependent variation.
长期的高雌激素和低雌激素都会影响血管和代谢功能。但是，微妙的性激素变化（例如在月经周期期间）是否也是如此尚不清楚。
研究了 21 名健康的体重正常的女性，她们的月经周期规律，在卵泡早期（第 3 天 +/- 2 天）、卵泡晚期（第 12 天 +/- 2 天）和黄体中期（第 20 天 +/- 3 天）进行了研究。通过皮肤离子电渗法（乙酰胆碱 [ACh] 和硝普钠 [SNP]）、动脉和静脉闭塞后的皮肤毛细血管募集（即毛细血管镜检查）以及静息皮肤激光多普勒血流的傅里叶分析（即血管舒缩运动）来评估微血管功能。在研究期间还测定了胰岛素敏感性（即稳态模型评估）和血压。
由于有 3 名女性无排卵，因此将其从分析中排除。ACh 和 SNP 的皮肤微血管反应、毛细血管功能、血管舒缩运动、胰岛素敏感性和血压在三个阶段之间没有差异（P > or = 0.1）。此外，微血管功能与血浆雌激素水平之间没有相关性（r = -0.06-0.2；P > or = 0.2）。
微血管功能没有表现出明显的月经周期依赖性变化。
