韩国人白细胞抗原 II 类等位基因与慢性萎缩性胃炎和胃癌的相关性。
Association of the human leukocyte antigen class II alleles with chronic atrophic gastritis and gastric carcinoma in Koreans.
机构信息
Department of Surgery, Hallym University Sacred Heart Hospital, Anyang, Korea.
出版信息
J Dig Dis. 2009 Nov;10(4):265-71. doi: 10.1111/j.1751-2980.2009.00395.x.
OBJECTIVE
Gastric carcinogenesis is a multi-step process and is influenced by several etiological agents, including the host's genetic factors. Since whether a patient remains with chronic superficial gastritis (CSG) or progresses to either chronic atrophic gastritis (CAG) or gastric carcinoma (GC) could be a genetic predisposition unique in each population, we hypothesized that host human leukocyte antigen (HLA) alleles could be discriminative in predicting the risk of CSG progression to precancerous CAG and GC in Koreans.
METHODS
A total of 165 patients with gastric disorders (CSG, 62; CAG, 69 and GC, 34), were selected to investigate the association of HLA class II alleles with the progression of CSG to CAG or GC. HLA genotypes were obtained by the polymerase chain reaction-sequence based typing method.
RESULTS
The phenotypic frequencies of DRB11101 and DQA10505 were significantly higher in the CAG group compared to those in the CSG group. In the subjects with Helicobacter pylori (H. pypori) (+), the frequencies of DRB11501 and DQB10602 were significantly lower in the CAG compared to those in the CSG. Further analysis showed that sex (P < 0.05, OR = 0.41-0.42) and age (P < 0.05, OR = 1.05) also affected the risk of progression from CSG to CAG in H. pylori (+) patients carrying the DRB11501 or DQB10602 allele. Additionally, the frequency of DRB1*0404 in the GC group was significantly higher than that in the gastritis group.
CONCLUSION
Our findings strongly imply an association between HLA class II alleles and the risk of CAG development and GC progression in Koreans.
目的
胃癌的发生是一个多步骤的过程，受到多种病因的影响，包括宿主的遗传因素。由于每个患者是否会从慢性浅表性胃炎（CSG）发展为慢性萎缩性胃炎（CAG）或胃癌（GC）可能是其特有的遗传倾向，因此我们假设人类白细胞抗原（HLA）等位基因在预测 CSG 向癌前 CAG 和 GC 进展的风险方面在韩国人群中具有区分能力。
方法
选择了 165 名患有胃部疾病的患者（CSG62 例；CAG69 例和 GC34 例），以研究 HLA Ⅱ类等位基因与 CSG 向 CAG 或 GC 进展的相关性。通过聚合酶链反应-序列基础分型方法获得 HLA 基因型。
结果
与 CSG 组相比，CAG 组中 DRB11101 和 DQA10505 的表型频率明显更高。在 H. pylori（H. pylori）（+）的受试者中，与 CSG 相比，CAG 中 DRB11501 和 DQB10602 的频率明显降低。进一步分析表明，在携带 DRB11501 或 DQB10602 等位基因的 H. pylori（+）患者中，性别（P<0.05，OR=0.41-0.42）和年龄（P<0.05，OR=1.05）也会影响从 CSG 进展为 CAG 的风险。此外，GC 组中 DRB1*0404 的频率明显高于胃炎组。
结论
我们的研究结果强烈表明 HLA Ⅱ类等位基因与韩国人群中 CAG 发生和 GC 进展的风险之间存在关联。
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