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韩国关联资源（KARE）队列研究中胃炎染色体内部的关联上位性网络

Relevance Epistasis Network of Gastritis for Intra-chromosomes in the Korea Associated Resource (KARE) Cohort Study.

作者信息

Jeong Hyun-Hwan, Sohn Kyung-Ah

机构信息

Department of Information and Computer Engineering, Ajou University, Suwon 443-749, Korea.

出版信息

Genomics Inform. 2014 Dec;12(4):216-24. doi: 10.5808/GI.2014.12.4.216. Epub 2014 Dec 31.

DOI:10.5808/GI.2014.12.4.216
PMID:25705161
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4330257/
Abstract

Gastritis is a common but a serious disease with a potential risk of developing carcinoma. Helicobacter pylori infection is reported as the most common cause of gastritis, but other genetic and genomic factors exist, especially single-nucleotide polymorphisms (SNPs). Association studies between SNPs and gastritis disease are important, but results on epistatic interactions from multiple SNPs are rarely found in previous genome-wide association (GWA) studies. In this study, we performed computational GWA case-control studies for gastritis in Korea Associated Resource (KARE) data. By transforming the resulting SNP epistasis network into a gene-gene epistasis network, we also identified potential gene-gene interaction factors that affect the susceptibility to gastritis.

摘要

胃炎是一种常见但严重的疾病，具有发展为癌症的潜在风险。据报道，幽门螺杆菌感染是胃炎最常见的病因，但其他遗传和基因组因素也存在，尤其是单核苷酸多态性（SNP）。SNP与胃炎疾病之间的关联研究很重要，但先前全基因组关联（GWA）研究中很少发现多个SNP上位性相互作用的结果。在本研究中，我们利用韩国关联资源（KARE）数据对胃炎进行了计算性GWA病例对照研究。通过将所得的SNP上位性网络转化为基因-基因上位性网络，我们还确定了影响胃炎易感性的潜在基因-基因相互作用因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c316/4330257/693308c25818/gni-12-216-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c316/4330257/d9cca95461c3/gni-12-216-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c316/4330257/645501c0e92e/gni-12-216-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c316/4330257/6f5e20cf97b0/gni-12-216-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c316/4330257/3c0ed0b768e6/gni-12-216-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c316/4330257/f2ed874ebc86/gni-12-216-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c316/4330257/e8c1340d18a3/gni-12-216-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c316/4330257/693308c25818/gni-12-216-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c316/4330257/d9cca95461c3/gni-12-216-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c316/4330257/645501c0e92e/gni-12-216-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c316/4330257/6f5e20cf97b0/gni-12-216-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c316/4330257/3c0ed0b768e6/gni-12-216-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c316/4330257/f2ed874ebc86/gni-12-216-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c316/4330257/e8c1340d18a3/gni-12-216-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c316/4330257/693308c25818/gni-12-216-g007.jpg

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