Sternberg Esther M, Judd Lewis L
National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
Ann N Y Acad Sci. 2009 Oct;1179:229-33. doi: 10.1111/j.1749-6632.2009.05059.x.
The discovery of glucocorticoids and their enormous therapeutic benefits led to the use of these compounds as valuable medications for a wide variety of diseases. In 1950 this effort was ushered in by a landmark event-the awarding of the 1950 Nobel Prize in Physiology and Medicine to Drs. Phillip Hench, Edward Kendall, and Tadeus Reichstein. It was Hench who described and researched the successful use of the glucocorticoid, cortisone, and pituitary adrenocorticotrophic hormones to treat rheumatoid arthritis. Significant scientific discovery preceded Hench and colleagues' efforts, but the revolutionary accumulation of discovery in glucocorticoids since then is one of the unique scientific stories in the history of medicine. The scientific conference upon which this volume is based represents an attempt to convene a state-of-the-science meeting on the current understanding and scientific status of this fascinating, far-reaching, and fast-moving field. This last chapter will summarize the exciting presentations of this 2-day conference.
糖皮质激素的发现及其巨大的治疗益处促使这些化合物被用作治疗多种疾病的重要药物。1950年，这一努力因一个具有里程碑意义的事件而拉开序幕——菲利普·亨奇博士、爱德华·肯德尔博士和塔德乌什·赖希施泰因博士被授予1950年诺贝尔生理学和医学奖。正是亨奇描述并研究了糖皮质激素可的松和垂体促肾上腺皮质激素在治疗类风湿性关节炎方面的成功应用。在亨奇及其同事开展相关工作之前已有重大的科学发现，但自那时起糖皮质激素领域革命性的发现积累却是医学史上独特的科学故事之一。本书所基于的科学会议旨在尝试召开一次关于这个迷人、影响深远且发展迅速的领域的当前认识和科学现状的科学现状会议。最后一章将总结这次为期两天会议上令人兴奋的演讲内容。
